PFKP

Phosphofructokinase, platelet, also known as PFKP is an enzyme which in humans is encoded by the PFKP gene.^[5]

PFKP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RH3, 4U1R, 4WL0, 4XYJ, 4XYK, 4XZ2
Identifiers
Aliases	PFKP, ATP-PFK, PFK-C, PFK-P, PFKF, phosphofructokinase, platelet
External IDs	OMIM: 171840; MGI: 1891833; HomoloGene: 20579; GeneCards: PFKP; OMA:PFKP - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.2 Start 3,066,333 bp[1] End 3,137,718 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 6,629,804 bp[2] End 6,698,813 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii saphenous vein spinal ganglia right frontal lobe left testis Brodmann area 9 right testis apex of heart right hemisphere of cerebellum sperm Top expressed in neural layer of retina facial motor nucleus superior frontal gyrus anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell cingulate gyrus Epithelium of choroid plexus spermatocyte central gray substance of midbrain pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein-containing complex binding metal ion binding kinase activity catalytic activity ATP binding 6-phosphofructokinase activity cadherin binding identical protein binding AMP binding monosaccharide binding fructose-6-phosphate binding Cellular component cytosol membrane extracellular exosome nucleus cytoplasm extracellular matrix 6-phosphofructokinase complex Biological process fructose 6-phosphate metabolic process glycolytic process phosphorylation canonical glycolysis metabolism cellular response to leukemia inhibitory factor glucose catabolic process fructose 1,6-bisphosphate metabolic process protein complex oligomerization protein homotetramerization glycolytic process through fructose-6-phosphate Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5214 56421 Ensembl ENSG00000067057 ENSMUSG00000021196 UniProt Q01813 Q9WUA3 RefSeq (mRNA) NM_001242339 NM_002627 NM_001323067 NM_001323068 NM_001323069 NM_001323070 NM_001323071 NM_001323072 NM_001323073 NM_001323074 NM_001345944 NM_001291071 NM_019703 RefSeq (protein) NP_001229268 NP_001309996 NP_001309997 NP_001309998 NP_001309999 NP_001310000 NP_001310001 NP_001310002 NP_001310003 NP_001332873 NP_002618 NP_001278000 NP_062677 Location (UCSC) Chr 10: 3.07 – 3.14 Mb Chr 13: 6.63 – 6.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose 6-phosphate to fructose 1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM) and liver (PFKL) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Full tetrameric phosphofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.^[5][6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".