PHB2

Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.^[5][6][7]

PHB2
Identifiers
Aliases	PHB2, BAP, BCAP37, Bap37, PNAS-141, REA, p22, hBAP, prohibitin 2, Prohibitin-2
External IDs	OMIM: 610704; MGI: 102520; HomoloGene: 5263; GeneCards: PHB2; OMA:PHB2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,965,327 bp[1] End 6,970,780 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 124,689,299 bp[2] End 124,693,913 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vulva nipple skin of arm vastus lateralis muscle triceps brachii muscle left ovary jejunal mucosa skin of thigh thymus glutes Top expressed in yolk sac embryo embryo ventricular zone tail of embryo right kidney lip esophagus muscle of thigh neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function protein N-terminus binding amide binding protein C-terminus binding protein binding estrogen receptor binding sphingolipid binding Cellular component cytoplasm membrane nuclear matrix cell surface mitochondrial outer membrane mitochondrion extracellular exosome nucleus cell periphery mitochondrial inner membrane axon postsynaptic density protein-containing complex presynaptic active zone glutamatergic synapse GABA-ergic synapse Biological process regulation of transcription, DNA-templated mammary gland branching involved in thelarche protein stabilization regulation of branching involved in mammary gland duct morphogenesis mitochondrion organization negative regulation of mammary gland epithelial cell proliferation positive regulation of DNA-binding transcription factor activity positive regulation of exit from mitosis mammary gland alveolus development negative regulation of DNA-binding transcription factor activity transcription, DNA-templated sister chromatid cohesion positive regulation of cell cycle G1/S phase transition positive regulation of ERK1 and ERK2 cascade negative regulation of transcription, DNA-templated negative regulation of intracellular estrogen receptor signaling pathway regulation of complement activation mitochondrial calcium ion transmembrane transport response to wounding negative regulation of apoptotic process cellular response to retinoic acid cellular response to hypoxia protein import into nucleus regulation of cytochrome-c oxidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11331 12034 Ensembl ENSG00000215021 ENSMUSG00000004264 UniProt Q99623 O35129 RefSeq (mRNA) NM_001144831 NM_001267700 NM_007531 RefSeq (protein) NP_001138303 NP_001254629 NP_031557 Location (UCSC) Chr 12: 6.97 – 6.97 Mb Chr 6: 124.69 – 124.69 Mb PubMed search [3] [4]
Wikidata
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Interactions

PHB2 has been shown to interact with PTMA.^[8]