PHPT1

14 kDa phosphohistidine phosphatase is an enzyme that in humans is encoded by the PHPT1 gene.^[5][6][7]

PHPT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AI6, 2HW4, 2NMM, 2OZW, 2OZX
Identifiers
Aliases	PHPT1, CGI-202, HEL-S-132P, HSPC141, PHP14, phosphohistidine phosphatase 1, PHP
External IDs	OMIM: 610167; MGI: 1922704; HomoloGene: 8573; GeneCards: PHPT1; OMA:PHPT1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 136,848,724 bp[1] End 136,851,027 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,463,442 bp[2] End 25,465,236 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh anterior pituitary right adrenal gland right adrenal cortex right auricle of heart body of pancreas right hemisphere of cerebellum left adrenal cortex C1 segment Top expressed in lens yolk sac quadriceps femoris muscle neural tube cerebellum olfactory bulb muscle tissue neural layer of retina cerebellar cortex skeletal muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel inhibitor activity phosphoprotein phosphatase activity hydrolase activity transmembrane transporter binding protein binding protein histidine phosphatase activity Cellular component cytoplasm cytosol extracellular exosome Biological process negative regulation of lyase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus protein dephosphorylation regulation of actin cytoskeleton reorganization peptidyl-histidine dephosphorylation negative regulation of ATP citrate synthase activity positive regulation of cell motility negative regulation of T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29085 75454 Ensembl ENSG00000054148 ENSMUSG00000036504 UniProt Q9NRX4 Q9DAK9 RefSeq (mRNA) NM_001135860 NM_001135861 NM_001287342 NM_001287343 NM_014172 NM_029293 RefSeq (protein) NP_001129333 NP_001274271 NP_001274272 NP_054891 NP_083569 Location (UCSC) Chr 9: 136.85 – 136.85 Mb Chr 2: 25.46 – 25.47 Mb PubMed search [3] [4]
Wikidata
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