PI4KA

Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene.^[5][6][7]

PI4KA
Identifiers
Aliases	PI4KA, PI4K-ALPHA, PIK4CA, pi4K230, PMGYCHA, phosphatidylinositol 4-kinase alpha, SPG84, GIDID2
External IDs	OMIM: 600286; MGI: 2448506; HomoloGene: 11171; GeneCards: PI4KA; OMA:PI4KA - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 20,707,691 bp[1] End 20,859,417 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,098,215 bp[2] End 17,224,178 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus right frontal lobe Brodmann area 9 right hemisphere of cerebellum primary visual cortex prefrontal cortex anterior cingulate cortex nucleus accumbens pituitary gland putamen Top expressed in substantia nigra superior frontal gyrus primary motor cortex prefrontal cortex subiculum medial dorsal nucleus medial geniculate nucleus medial vestibular nucleus dorsal striatum neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding 1-phosphatidylinositol 4-kinase activity kinase activity cadherin binding Cellular component cytoplasm Golgi-associated vesicle membrane cytosol extracellular exosome membrane focal adhesion plasma membrane Biological process phosphatidylinositol biosynthetic process phosphatidylinositol phosphate biosynthetic process signal transduction viral RNA genome replication phosphorylation actin cytoskeleton organization phosphatidylinositol-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5297 224020 Ensembl ENSG00000241973 ENSMUSG00000041720 UniProt P42356 E9Q3L2 RefSeq (mRNA) NM_002650 NM_058004 NM_001362862 NM_001362863 NM_001001983 NM_001373955 RefSeq (protein) NP_477352 NP_001349791 NP_001349792 NP_001001983 Location (UCSC) Chr 22: 20.71 – 20.86 Mb Chr 16: 17.1 – 17.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene.^[7]

Clinical significance

The alpha isoform of PI4KIII plays a role in replication of hepatitis C virus (HCV).^[8] Furthermore, the PI4KA lipid kinase affects HCV replication by altering phosphorylation of the HCV NS5A protein.^[9]