PIAS1

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.^[5][6][7]

PIAS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V66
Identifiers
Aliases	PIAS1, DDXBP1, GBP, GU/RH-II, ZMIZ3, protein inhibitor of activated STAT 1
External IDs	OMIM: 603566; MGI: 1913125; HomoloGene: 22953; GeneCards: PIAS1; OMA:PIAS1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 68,054,309 bp[1] End 68,198,603 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 62,785,650 bp[2] End 62,895,206 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte seminal vesicula nipple caput epididymis tail of epididymis bone marrow cells cardia trabecular bone Achilles tendon buccal mucosa cell Top expressed in zygote spermatid secondary oocyte primary oocyte seminiferous tubule pineal gland genital tubercle spermatocyte olfactory tubercle granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription corepressor activity transcription coactivator activity zinc ion binding transcription factor binding metal ion binding SUMO ligase activity protein binding androgen receptor binding enzyme binding ubiquitin protein ligase binding protein domain specific binding SUMO transferase activity transferase activity protein C-terminus binding Cellular component PML body nuclear speck nucleoplasm nucleus Biological process androgen receptor signaling pathway receptor signaling pathway via JAK-STAT regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II protein sumoylation transcription, DNA-templated regulation of interferon-gamma-mediated signaling pathway regulation of cell population proliferation fat cell differentiation positive regulation of proteasomal ubiquitin-dependent protein catabolic process visual learning negative regulation of apoptotic process positive regulation of smooth muscle cell differentiation spermatogenesis positive regulation of protein sumoylation protein-DNA complex assembly positive regulation of transcription, DNA-templated G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8554 56469 Ensembl ENSG00000033800 ENSMUSG00000032405 UniProt O75925 O88907 RefSeq (mRNA) NM_016166 NM_001320687 NM_019663 RefSeq (protein) NP_001307616 NP_057250 NP_062637 Location (UCSC) Chr 15: 68.05 – 68.2 Mb Chr 9: 62.79 – 62.9 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.^[7]

Interactions

PIAS1 has been shown to interact with:

• DNMT3A,^[8]
• P53,^[9][10]
• STAT1,^[11]
• Small ubiquitin-related modifier 1,^[9][12]
• Sp3 transcription factor,^[13] and
• UBE2I.^[9][12][13]