Protein inhibitor of activated STAT2

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.^[5][6][7]

PIAS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ASQ, 4FO9
Identifiers
Aliases	PIAS2, ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, Protein inhibitor of activated STAT2, protein inhibitor of activated STAT 2
External IDs	OMIM: 603567; MGI: 1096566; HomoloGene: 20979; GeneCards: PIAS2; OMA:PIAS2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.1 Start 46,803,218 bp[1] End 46,920,160 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E3 Start 77,152,904 bp[2] End 77,241,496 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis epithelium of colon secondary oocyte testicle gastrocnemius muscle buccal mucosa cell cerebellar vermis internal globus pallidus Top expressed in seminiferous tubule spermatid spermatocyte ventricular zone Gonadal ridge ganglionic eminence lens tail of embryo neural layer of retina medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity zinc ion binding transcription factor binding metal ion binding SUMO ligase activity ligase activity protein binding androgen receptor binding ubiquitin protein ligase binding SUMO transferase activity transferase activity Cellular component PML body nuclear speck nuclear body nucleoplasm nucleus Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of androgen receptor signaling pathway negative regulation of DNA-binding transcription factor activity transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II protein sumoylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9063 17344 Ensembl ENSG00000078043 ENSMUSG00000025423 UniProt O75928 Q8C5D8 RefSeq (mRNA) NM_004671 NM_173206 NM_001324046 NM_001324047 NM_001324048 NM_001324049 NM_001324051 NM_001324052 NM_001324053 NM_001324054 NM_001324055 NM_001324057 NM_001324058 NM_001324059 NM_001324060 NM_001354033 NM_001354034 NM_001354035 NM_001354036 NM_001354037 NM_001354038 NM_001354039 NM_001164167 NM_001164168 NM_001164169 NM_001164170 NM_008602 RefSeq (protein) NP_001310975 NP_001310976 NP_001310977 NP_001310978 NP_001310980 NP_001310981 NP_001310982 NP_001310983 NP_001310984 NP_001310986 NP_001310987 NP_001310988 NP_001310989 NP_004662 NP_775298 NP_001340962 NP_001340963 NP_001340964 NP_001340965 NP_001340966 NP_001340967 NP_001340968 NP_001157639 NP_001157640 NP_001157641 NP_001157642 NP_032628 Location (UCSC) Chr 18: 46.8 – 46.92 Mb Chr 18: 77.15 – 77.24 Mb PubMed search [3] [4]
Wikidata
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Interactions

Protein inhibitor of activated STAT2 has been shown to interact with:

• Androgen receptor,^[8][9]
• DNMT3A,^[10]
• PARK7,^[11] and
• UBE2I.^[12][13]