PIAS4

E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as a protein inhibitor of activated STAT protein gamma (PIASg or PIASy), and is an enzyme that in humans is encoded by the PIAS4 gene.^[5][6]

PIAS4
Identifiers
Aliases	PIAS4, PIASY, Piasg, ZMIZ6, PIAS-gamma, protein inhibitor of activated STAT 4
External IDs	OMIM: 605989; MGI: 2136940; HomoloGene: 104136; GeneCards: PIAS4; OMA:PIAS4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,007,736 bp[1] End 4,039,386 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,989,100 bp[2] End 81,003,757 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis right hemisphere of cerebellum stromal cell of endometrium oocyte sural nerve islet of Langerhans muscle of thigh muscle layer of sigmoid colon monocyte Top expressed in seminiferous tubule internal carotid artery spermatid external carotid artery tibiofemoral joint primary oocyte crypt of lieberkuhn of small intestine secondary oocyte granulocyte zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription corepressor activity zinc ion binding metal ion binding SUMO ligase activity protein binding ubiquitin protein ligase binding SUMO transferase activity transferase activity protein C-terminus binding Cellular component cytoplasm PML body nuclear matrix transferase complex nucleus nucleoplasm Biological process regulation of transcription, DNA-templated positive regulation of keratinocyte apoptotic process negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of transcription by RNA polymerase II Wnt signaling pathway positive regulation of protein sumoylation protein sumoylation transcription, DNA-templated positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of transcription, DNA-templated double-strand break repair via nonhomologous end joining negative regulation of NF-kappaB transcription factor activity vitamin D metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51588 59004 Ensembl ENSG00000105229 ENSMUSG00000004934 UniProt Q8N2W9 Q9JM05 RefSeq (mRNA) NM_015897 NM_016149 NM_021501 RefSeq (protein) NP_056981 NP_067476 Location (UCSC) Chr 19: 4.01 – 4.04 Mb Chr 10: 80.99 – 81 Mb PubMed search [3] [4]
Wikidata
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Interactions

PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6,^[7] Mothers against decapentaplegic homolog 7^[7] and Lymphoid enhancer-binding factor 1.^[8] PIAS4 has been shown to be responsible for the SUMOylation of inhibited Werner syndrome helicase (WRN) trapped on DNA in microsatellite unstable cancer cells. ^[9]