PIB5PA

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A is an enzyme that in humans is encoded by the INPP5J gene.^[5][6]

INPP5J
Identifiers
Aliases	INPP5J, INPP5, PIB5PA, PIPP, inositol polyphosphate-5-phosphatase J
External IDs	OMIM: 606481; MGI: 2158663; HomoloGene: 8682; GeneCards: INPP5J; OMA:INPP5J - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 31,122,731 bp[1] End 31,134,697 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,494,375 bp[2] End 3,504,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right hemisphere of cerebellum mucosa of transverse colon parotid gland apex of heart right auricle of heart left ventricle duodenum body of pancreas Top expressed in cerebellar cortex submandibular gland primary visual cortex CA3 field superior frontal gyrus perirhinal cortex entorhinal cortex dentate gyrus of hippocampal formation granule cell masseter muscle medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding inositol-polyphosphate 5-phosphatase activity protein binding hydrolase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Cellular component cytoplasm ruffle growth cone dendritic shaft cytosol plasma membrane Biological process phosphatidylinositol biosynthetic process negative regulation of neuron projection development inositol phosphate metabolic process negative regulation of microtubule polymerization phosphatidylinositol dephosphorylation negative regulation of peptidyl-serine phosphorylation inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27124 170835 Ensembl ENSG00000185133 ENSMUSG00000034570 UniProt Q15735 P59644 RefSeq (mRNA) NM_001002837 NM_001284285 NM_001284286 NM_001284287 NM_001284288 NM_001284289 NM_014422 NM_172439 RefSeq (protein) NP_001002837 NP_001271214 NP_001271215 NP_001271216 NP_001271217 NP_001271218 NP_766027 Location (UCSC) Chr 22: 31.12 – 31.13 Mb Chr 11: 3.49 – 3.5 Mb PubMed search [3] [4]
Wikidata
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