PICK1

Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.^[5][6]

PICK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GZV
Identifiers
Aliases	PICK1, PICK, PRKCABP, protein interacting with PRKCA 1
External IDs	OMIM: 605926; MGI: 894645; HomoloGene: 7470; GeneCards: PICK1; OMA:PICK1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,056,311 bp[1] End 38,075,701 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,113,373 bp[2] End 79,133,684 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right hemisphere of cerebellum right uterine tube left ovary right frontal lobe left testis right testis gastric mucosa right ovary body of pancreas Top expressed in neural layer of retina spermatid muscle of thigh spermatocyte superior frontal gyrus right kidney lip crypt of lieberkuhn of small intestine extensor digitorum longus muscle ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding Arp2/3 complex binding metal ion binding actin filament binding protein C-terminus binding protein binding identical protein binding enzyme binding actin binding signaling receptor binding G protein-coupled receptor binding protein kinase C binding phospholipid binding Cellular component cytoplasm endocytic vesicle membrane postsynaptic membrane Golgi apparatus postsynaptic density membrane plasma membrane synapse cell junction perinuclear region of cytoplasm neuron projection cytoskeleton presynaptic membrane mitochondrion cytosol aggresome synaptic vesicle trans-Golgi network membrane postsynaptic early endosome Biological process cellular response to glucose starvation glial cell development retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum positive regulation of receptor internalization neuronal ion channel clustering regulation of Arp2/3 complex-mediated actin nucleation monoamine transport receptor clustering DNA methylation involved in gamete generation negative regulation of Arp2/3 complex-mediated actin nucleation dendritic spine organization dendritic spine maintenance protein phosphorylation protein kinase C-activating G protein-coupled receptor signaling pathway long-term depression cellular response to decreased oxygen levels DNA methylation involved in embryo development intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9463 18693 Ensembl ENSG00000100151 ENSMUSG00000068206 UniProt Q9NRD5 Q62083 RefSeq (mRNA) NM_001039583 NM_001039584 NM_012407 NM_001045558 NM_008837 RefSeq (protein) NP_001034672 NP_001034673 NP_036539 NP_001034672.1 NP_001034673.1 NP_036539.1 n/a Location (UCSC) Chr 22: 38.06 – 38.08 Mb Chr 15: 79.11 – 79.13 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.^[7]

Interactions

PICK1 has been shown to interact with:

• ACCN2,^[8][9]
• BNC1,^[9]
• Dopamine transporter,^[10]
• GRIA2,^[11]
• GRIA3,^[11]
• GRIA4,^[11]
• GRIK1,^[12]
• GRIK2,^[12]
• GRIK3,^[11]
• HER2/neu,^[13]
• Metabotropic glutamate receptor 3,^[11] and
• Metabotropic glutamate receptor 7.^[14]