PIGB

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.^[5][6]

PIGB
Identifiers
Aliases	PIGB, GPI-MT-III, PIG-B, phosphatidylinositol glycan anchor biosynthesis class B, EIEE80, DEE80
External IDs	OMIM: 604122; MGI: 1891825; HomoloGene: 3570; GeneCards: PIGB; OMA:PIGB - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.3 Start 55,318,960 bp[1] End 55,355,648 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 D Start 72,914,701 bp[2] End 72,947,660 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood Achilles tendon monocyte anterior pituitary left lobe of thyroid gland right lobe of thyroid gland body of pancreas gastric mucosa spleen Top expressed in ascending aorta aortic valve granulocyte tail of embryo genital tubercle neural layer of retina dentate gyrus of hippocampal formation granule cell supraoptic nucleus right kidney zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity mannosyltransferase activity glycosyltransferase activity glycolipid mannosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane mannosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9488 55981 Ensembl ENSG00000069943 ENSMUSG00000079469 UniProt Q92521 Q9JJQ0 RefSeq (mRNA) NM_004855 NM_018889 RefSeq (protein) NP_004846 NP_061377 Location (UCSC) Chr 15: 55.32 – 55.36 Mb Chr 9: 72.91 – 72.95 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.^[6]