PIGU

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.^[5][6][7]

PIGU
Identifiers
Aliases	PIGU, CDC91L1, GAB1, phosphatidylinositol glycan anchor biosynthesis class U, GPIBD21, NEDBSS
External IDs	OMIM: 608528; MGI: 3039607; HomoloGene: 6553; GeneCards: PIGU; OMA:PIGU - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 34,560,542 bp[1] End 34,698,790 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,120,163 bp[2] End 155,199,350 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon ganglionic eminence ventricular zone islet of Langerhans C1 segment oocyte tibialis anterior muscle gonad rectum right uterine tube Top expressed in external carotid artery internal carotid artery genital tubercle tail of embryo muscle of thigh yolk sac right kidney proximal tubule conjunctival fornix primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function GPI-anchor transamidase activity GPI anchor binding Cellular component integral component of membrane integral component of endoplasmic reticulum membrane plasma membrane endoplasmic reticulum membrane membrane endoplasmic reticulum GPI-anchor transamidase complex Biological process GPI anchor biosynthetic process regulation of receptor signaling pathway via JAK-STAT attachment of GPI anchor to protein protein localization to cell surface Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128869 228812 Ensembl ENSG00000101464 ENSMUSG00000038383 UniProt Q9H490 Q3TAA8 RefSeq (mRNA) NM_080476 NM_001004721 RefSeq (protein) NP_536724 NP_001004721 Location (UCSC) Chr 20: 34.56 – 34.7 Mb Chr 2: 155.12 – 155.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.^[7]