PIK3C2B

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.^[5][6][7]

PIK3C2B
Identifiers
Aliases	PIK3C2B, C2-PI3K, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
External IDs	OMIM: 602838; MGI: 2685045; HomoloGene: 20582; GeneCards: PIK3C2B; OMA:PIK3C2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 204,422,628 bp[1] End 204,494,805 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 132,973,405 bp[2] End 133,036,425 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell inferior ganglion of vagus nerve gingival epithelium pylorus nipple vena cava ventral tegmental area epithelium of nasopharynx visceral pleura superficial temporal artery Top expressed in zygote secondary oocyte primary oocyte tail of embryo skeletal muscle tissue striatum of neuraxis genital tubercle heart muscle of thigh colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding lipid kinase activity 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity kinase activity protein binding phosphatidylinositol binding ATP binding Cellular component phosphatidylinositol 3-kinase complex membrane intracellular membrane-bounded organelle plasma membrane endocytic vesicle endoplasmic reticulum nucleus nucleoplasm cytosol cytoplasm Biological process protein kinase B signaling phosphorylation phosphatidylinositol phosphate biosynthetic process phosphatidylinositol-mediated signaling cellular response to starvation phosphatidylinositol-3-phosphate biosynthetic process autophagosome organization macroautophagy phosphatidylinositol 3-kinase signaling cell migration biological process phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5287 240752 Ensembl ENSG00000133056 ENSMUSG00000026447 UniProt O00750 n/a RefSeq (mRNA) NM_002646 NM_001377334 NM_001377335 NM_001099276 RefSeq (protein) NP_002637 NP_001364263 NP_001364264 n/a Location (UCSC) Chr 1: 204.42 – 204.49 Mb Chr 1: 132.97 – 133.04 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not Ca²⁺, which suggests that this enzyme may function in a calcium-independent manner.^[7]