PIK3C3

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene.^[5][6] It's a class III phosphoinositide 3-kinase.

PIK3C3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IHY, 3LS8, 4OYS, 4PH4, 4UWF, 4UWG, 4UWH, 4UWL, 5ANL
Identifiers
Aliases	PIK3C3, VPS34, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3
External IDs	OMIM: 602609; MGI: 2445019; HomoloGene: 1986; GeneCards: PIK3C3; OMA:PIK3C3 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.3 Start 41,955,234 bp[1] End 42,087,830 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 30,405,800 bp[2] End 30,481,179 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone endothelial cell stromal cell of endometrium ganglionic eminence testicle gonad right adrenal cortex right testis left testis Top expressed in lesser wing of sphenoid bone occiput occipital bone Meckel's cartilage rib parotid gland epithelium of stomach submandibular gland granulocyte Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding 1-phosphatidylinositol-3-kinase activity protein binding phosphatidylinositol 3-kinase activity ATP binding kinase activity Cellular component cytosol endosome late endosome phagocytic vesicle membrane membrane phosphatidylinositol 3-kinase complex, class III autophagosome midbody phagocytic vesicle axoneme cytoplasmic vesicle autolysosome phagophore assembly site peroxisome phosphatidylinositol 3-kinase complex, class III, type I phosphatidylinositol 3-kinase complex, class III, type II cytoplasm intracellular anatomical structure Biological process cellular response to glucose starvation regulation of cytokinesis phosphorylation protein processing response to leucine cytokinesis endosome organization cell division phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process early endosome to late endosome transport phosphatidylinositol biosynthetic process cell cycle toll-like receptor 9 signaling pathway macroautophagy regulation of protein secretion protein localization to phagophore assembly site cellular response to starvation protein lipidation autophagy autophagosome assembly protein phosphorylation endocytosis autophagy of peroxisome phosphatidylinositol-mediated signaling interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5289 225326 Ensembl ENSG00000078142 ENSMUSG00000033628 UniProt Q8NEB9 Q6PF93 RefSeq (mRNA) NM_001308020 NM_002647 NM_181414 RefSeq (protein) NP_001294949 NP_002638 NP_852079 Location (UCSC) Chr 18: 41.96 – 42.09 Mb Chr 18: 30.41 – 30.48 Mb PubMed search [3] [4]
Wikidata
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