PIK3IP1

Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.^[4][5]

PIK3IP1
Identifiers
Aliases	PIK3IP1, HGFL, hHGFL(S), phosphoinositide-3-kinase interacting protein 1, TrIP
External IDs	MGI: 1917016; HomoloGene: 14166; GeneCards: PIK3IP1; OMA:PIK3IP1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 31,281,594 bp[1] End 31,292,534 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node olfactory zone of nasal mucosa right lung granulocyte blood gastric mucosa spleen tibial nerve skin of leg skin of abdomen n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol 3-kinase catalytic subunit binding protein binding Cellular component integral component of membrane plasma membrane membrane Biological process negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of phosphatidylinositol 3-kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113791 216505 Ensembl ENSG00000100100 n/a UniProt Q96FE7 Q7TMJ8 RefSeq (mRNA) NM_052880 NM_001135911 NM_178149 RefSeq (protein) NP_001129383 NP_443112 NP_835362 Location (UCSC) Chr 22: 31.28 – 31.29 Mb n/a PubMed search [2] [3]
Wikidata
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PIK3IP1 is a transmembrane protein that binds to PI3K, reducing signal to the PI3K/AKT/mTOR pathway.^[6] Through this mechanism, PIK3IP1 inhibits cell proliferation in tumor cells and is associated with cancer. PIK3IP1 is also associated with the inflammatory response and autoimmune diseases.^[6]