PIK3R3

Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.^[5][6]

PIK3R3
Identifiers
Aliases	PIK3R3, p55, p55-GAMMA, p55PIK, phosphoinositide-3-kinase regulatory subunit 3, PI3KR3
External IDs	OMIM: 606076; MGI: 109277; HomoloGene: 2690; GeneCards: PIK3R3; OMA:PIK3R3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 46,040,140 bp[1] End 46,133,036 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 116,078,815 bp[2] End 116,160,253 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis paraflocculus of cerebellum nasal epithelium lower lobe of lung right hemisphere of cerebellum mucosa of paranasal sinus right ventricle right lung testicle ganglionic eminence Top expressed in cerebellar vermis lobe of cerebellum zygote hand ganglionic eminence otic vesicle inferior colliculi suprachiasmatic nucleus pontine nuclei secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol 3-kinase regulator activity protein binding 1-phosphatidylinositol-3-kinase activity phosphotyrosine residue binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytosol phosphatidylinositol 3-kinase complex Biological process regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process insulin receptor signaling pathway positive regulation of protein phosphorylation cell migration involved in sprouting angiogenesis positive regulation of gene expression protein kinase B signaling positive regulation of cell migration phosphatidylinositol phosphate biosynthetic process phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8503 18710 Ensembl ENSG00000117461 ENSMUSG00000028698 UniProt Q92569 Q64143 RefSeq (mRNA) NM_001114172 NM_001303428 NM_001303429 NM_001328648 NM_001328649 NM_001328650 NM_001328651 NM_001328652 NM_001328653 NM_001328654 NM_003629 NM_181585 NM_001355584 NM_001355585 NM_001355586 RefSeq (protein) NP_001107644 NP_001290357 NP_001290358 NP_001315577 NP_001315578 NP_001315579 NP_001315580 NP_001315581 NP_001315582 NP_001315583 NP_003620 NP_853616 NP_001342513 NP_001342514 NP_001342515 Location (UCSC) Chr 1: 46.04 – 46.13 Mb Chr 4: 116.08 – 116.16 Mb PubMed search [3] [4]
Wikidata
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Interactions

PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,^[7] IRS1^[7][8] and Retinoblastoma protein.^[9]