PIP4K2B

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.^[5][6][7][8]

PIP4K2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BO1, 3WZZ, 3X01, 3X02, 3X03, 3X04, 3X05, 3X06, 3X07, 3X08, 3X09, 3X0A, 3X0B, 3X0C
Identifiers
Aliases	PIP4K2B, PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
External IDs	OMIM: 603261; MGI: 1934234; HomoloGene: 2634; GeneCards: PIP4K2B; OMA:PIP4K2B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 38,765,691 bp[1] End 38,800,126 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.07 cM Start 97,605,983 bp[2] End 97,635,530 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Brodmann area 9 right frontal lobe anterior cingulate cortex prefrontal cortex ventricular zone cerebellar hemisphere right hemisphere of cerebellum muscle of leg muscle of thigh Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex muscle of thigh internal carotid artery superior frontal gyrus external carotid artery hand gastrocnemius muscle foot facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding 1-phosphatidylinositol-4-phosphate 5-kinase activity kinase activity phosphatidylinositol phosphate kinase activity protein binding ATP binding 1-phosphatidylinositol-3-phosphate 4-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity protein homodimerization activity Cellular component cytoplasm cytosol endoplasmic reticulum membrane membrane plasma membrane autophagosome endoplasmic reticulum nucleus nucleoplasm Biological process phosphatidylinositol metabolic process positive regulation of autophagosome assembly phosphorylation cell surface receptor signaling pathway regulation of autophagy phosphatidylinositol biosynthetic process phosphatidylinositol phosphate biosynthetic process regulation of phosphatidylinositol 3-kinase signaling phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8396 108083 Ensembl ENSG00000277292 ENSG00000276293 ENSMUSG00000018547 UniProt P78356 Q80XI4 RefSeq (mRNA) NM_003559 NM_138687 NM_054051 RefSeq (protein) NP_003550 NP_473392 Location (UCSC) Chr 17: 38.77 – 38.8 Mb Chr 11: 97.61 – 97.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.^[8]

Interactions

PIP4K2B has been shown to interact with TNFRSF1A.^[5] In addition, PIP4K2B has been shown to interact with PIP4K2A and may modulate the cellular localisation of PIP4K2A.^[9]

Structure

The structure of PIP4K2B has been determined through X-ray crystallography.^[10]