PIP5K1C

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma is an enzyme that in humans is encoded by the PIP5K1C gene.^[5][6]

PIP5K1C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G35, 3H1Z, 3H85
Identifiers
Aliases	PIP5K1C, LCCS3, PIP5K-GAMMA, PIP5K1-gamma, PIP5Kgamma, phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
External IDs	OMIM: 606102; MGI: 1298224; HomoloGene: 69032; GeneCards: PIP5K1C; OMA:PIP5K1C - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,630,183 bp[1] End 3,700,468 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,292,963 bp[2] End 81,319,973 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum decidua Brodmann area 10 left testis right testis paraflocculus of cerebellum right frontal lobe cerebellar vermis middle temporal gyrus stromal cell of endometrium Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell prefrontal cortex cerebellar cortex external carotid artery internal carotid artery primary visual cortex Rostral migratory stream granulocyte neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding kinase activity protein binding phosphatidylinositol phosphate kinase activity ATP binding phosphatidylinositol-3,4-bisphosphate 5-kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity 1-phosphatidylinositol-3-phosphate 4-kinase activity Cellular component cytoplasm cell projection membrane focal adhesion adherens junction plasma membrane ruffle membrane cell junction uropod phagocytic cup endomembrane system nucleus presynapse synapse nucleoplasm cytosol endosome membrane Biological process endocytosis phosphatidylinositol metabolic process adherens junction assembly phosphorylation synaptic vesicle exocytosis neutrophil chemotaxis chemotaxis clathrin-dependent endocytosis phosphatidylinositol phosphate biosynthetic process cell adhesion synaptic vesicle endocytosis phagocytosis phosphatidylinositol biosynthetic process actin cytoskeleton organization exocytosis regulation of phosphatidylinositol 3-kinase signaling membrane organization cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23396 18717 Ensembl ENSG00000186111 ENSMUSG00000034902 UniProt O60331 O70161 RefSeq (mRNA) NM_001195733 NM_001300849 NM_012398 NM_001146687 NM_001293646 NM_001293647 NM_008844 RefSeq (protein) NP_001182662 NP_001287778 NP_036530 NP_001140159 NP_001280575 NP_001280576 NP_032870 Location (UCSC) Chr 19: 3.63 – 3.7 Mb Chr 10: 81.29 – 81.32 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.^[6]