PIWIL1

Piwi-like protein 1 is a protein that in humans is encoded by the PIWIL1 gene.^[5][6][7]

PIWIL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L5C, 2L5D, 3O3I, 3O6E, 3O7V
Identifiers
Aliases	PIWIL1, CT80.1, HIWI, MIWI, PIWI, piwi like RNA-mediated gene silencing 1
External IDs	OMIM: 605571; MGI: 1928897; HomoloGene: 37963; GeneCards: PIWIL1; OMA:PIWIL1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 130,337,887 bp[1] End 130,372,637 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G1.3|5 67.86 cM Start 128,779,588 bp[2] End 128,832,538 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad testicle anterior pituitary right lobe of thyroid gland right uterine tube canal of the cervix spleen superior frontal gyrus Top expressed in spermatocyte seminiferous tubule zygote secondary oocyte spermatid female urethra primary oocyte primary spermatocyte embryo Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding RNA binding single-stranded RNA binding nucleic acid binding protein binding mRNA binding nuclease activity endonuclease activity endoribonuclease activity hydrolase activity metal ion binding piRNA binding protein-containing complex binding polysome binding mRNA cap binding complex binding Cellular component polysome nucleus mRNA cap binding complex dense body P granule cytoplasm chromatoid body Biological process multicellular organism development regulation of translation meiosis cell differentiation gene silencing spermatogenesis negative regulation of transposition piRNA metabolic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9271 57749 Ensembl ENSG00000275051 ENSG00000125207 ENSMUSG00000029423 UniProt Q96J94 Q9JMB7 RefSeq (mRNA) NM_001190971 NM_004764 NM_021311 RefSeq (protein) NP_001177900 NP_004755 NP_067286 Location (UCSC) Chr 12: 130.34 – 130.37 Mb Chr 5: 128.78 – 128.83 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms.

The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.^[7]