PLA2G10

Group 10 secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G10 gene.^[5][6]

PLA2G10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LE6, 1LE7, 4UY1
Identifiers
Aliases	PLA2G10, GXPLA2, GXSPLA2, SPLA2, sPLA2-X, phospholipase A2 group X
External IDs	OMIM: 603603; MGI: 1347522; HomoloGene: 2636; GeneCards: PLA2G10; OMA:PLA2G10 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.12 Start 14,672,548 bp[1] End 14,694,308 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 9.5 cM Start 13,532,921 bp[2] End 13,548,847 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum olfactory zone of nasal mucosa testicle duodenum right uterine tube right lung body of stomach body of pancreas upper lobe of left lung Top expressed in epithelium of stomach mucous cell of stomach left colon pyloric antrum spermatid seminiferous tubule Ileal epithelium embryo morula blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phospholipase A2 activity phospholipase activity metal ion binding hydrolase activity phospholipid binding calcium-dependent phospholipase A2 activity Cellular component extracellular region extracellular space Biological process phosphatidic acid biosynthetic process positive regulation of protein metabolic process phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling lysophospholipid transport lipid metabolism positive regulation of lipid storage phosphatidylinositol acyl-chain remodeling negative regulation of DNA-binding transcription factor activity axon guidance lipid catabolic process positive regulation of prostaglandin secretion positive regulation of macrophage derived foam cell differentiation positive regulation of arachidonic acid secretion phosphatidylglycerol acyl-chain remodeling negative regulation of cholesterol efflux cholesterol homeostasis arachidonic acid metabolic process phosphatidylcholine acyl-chain remodeling regulation of macrophage activation phospholipid metabolic process arachidonic acid secretion cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8399 26565 Ensembl ENSG00000276870 ENSG00000069764 ENSMUSG00000022683 UniProt O15496 Q9QXX3 RefSeq (mRNA) NM_003561 NM_001291009 NM_011987 RefSeq (protein) NP_003552 NP_001277938 NP_036117 Location (UCSC) Chr 16: 14.67 – 14.69 Mb Chr 16: 13.53 – 13.55 Mb PubMed search [3] [4]
Wikidata
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See also

• Phospholipase A₂