PLA2G2A

Phospholipase A₂, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene.^[5][6]

PLA2G2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AYP, 1BBC, 1DB4, 1DB5, 1DCY, 1J1A, 1KQU, 1KVO, 1N28, 1N29, 1POD, 1POE, 3U8B, 3U8D, 3U8H, 3U8I
Identifiers
Aliases	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2, phospholipase A2 group IIA
External IDs	OMIM: 172411; MGI: 104642; HomoloGene: 254; GeneCards: PLA2G2A; OMA:PLA2G2A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 19,975,431 bp[1] End 19,980,416 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 70.57 cM Start 138,559,171 bp[2] End 138,562,497 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva pericardium right coronary artery tendon of biceps brachii mucosa of ileum synovial joint gastric mucosa right auricle of heart left coronary artery rectum Top expressed in crypt of lieberkuhn of small intestine duodenum jejunum Paneth cell ankle joint Ileal epithelium morula gastrula intercostal muscle submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding calcium-dependent phospholipase A2 activity metal ion binding hydrolase activity phospholipid binding phospholipase A2 activity Cellular component membrane endoplasmic reticulum membrane secretory granule endoplasmic reticulum perinuclear region of cytoplasm extracellular exosome extracellular region plasma membrane extracellular space Biological process phosphatidic acid biosynthetic process phosphatidylserine acyl-chain remodeling positive regulation of inflammatory response phosphatidylethanolamine acyl-chain remodeling lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process positive regulation of macrophage derived foam cell differentiation low-density lipoprotein particle remodeling positive regulation of ERK1 and ERK2 cascade phosphatidylglycerol acyl-chain remodeling phosphatidic acid metabolic process phosphatidylcholine acyl-chain remodeling defense response to Gram-positive bacterium phospholipid metabolic process antimicrobial humoral response arachidonic acid secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5320 18780 Ensembl ENSG00000188257 ENSMUSG00000058908 UniProt P14555 P31482 RefSeq (mRNA) NM_001161729 NM_000300 NM_001161727 NM_001161728 NM_001395463 NM_001082531 NM_011108 RefSeq (protein) NP_000291 NP_001155199 NP_001155200 NP_001155201 NP_001076000 Location (UCSC) Chr 1: 19.98 – 19.98 Mb Chr 4: 138.56 – 138.56 Mb PubMed search [3] [4]
Wikidata
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See also

• Phospholipase A₂