PLA2G2D

Group IID secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G2D gene.^[5][6]

PLA2G2D
Identifiers
Aliases	PLA2G2D, PLA2IID, SPLASH, sPLA2-IID, sPLA2S, phospholipase A2 group IID
External IDs	OMIM: 605630; MGI: 1341796; HomoloGene: 7892; GeneCards: PLA2G2D; OMA:PLA2G2D - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 20,111,939 bp[1] End 20,119,566 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 70.57 cM Start 138,503,046 bp[2] End 138,509,357 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node appendix thymus testicle bone marrow cells rectum spleen mucosa of transverse colon gallbladder pharynx Top expressed in mesenteric lymph nodes spleen interventricular septum thymus sciatic nerve subcutaneous adipose tissue white adipose tissue muscle of thigh lip lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phospholipase A2 activity heparin binding metal ion binding heparan sulfate proteoglycan binding hydrolase activity phospholipid binding calcium-dependent phospholipase A2 activity Cellular component extracellular region Biological process phosphatidic acid biosynthetic process phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process negative regulation of T cell proliferation phosphatidylglycerol acyl-chain remodeling inflammatory response negative regulation of T cell activation phosphatidylcholine acyl-chain remodeling phospholipid metabolic process arachidonic acid secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26279 18782 Ensembl ENSG00000117215 ENSMUSG00000041202 UniProt Q9UNK4 Q9WVF6 RefSeq (mRNA) NM_012400 NM_001271814 NM_011109 NM_001347230 RefSeq (protein) NP_001258743 NP_036532 NP_001334159 NP_035239 Location (UCSC) Chr 1: 20.11 – 20.12 Mb Chr 4: 138.5 – 138.51 Mb PubMed search [3] [4]
Wikidata
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See also

• Phospholipase A₂