PLA2G4A

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

PLA2G4A

Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene.[5][6]

Quick Facts Available structures, PDB ...
PLA2G4A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLA2G4A, PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP
External IDsOMIM: 600522; MGI: 1195256; HomoloGene: 32059; GeneCards: PLA2G4A; OMA:PLA2G4A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001311193
NM_024420

NM_008869
NM_001305632

RefSeq (protein)

NP_001298122
NP_077734

NP_001292561
NP_032895

Location (UCSC)Chr 1: 186.83 – 186.99 MbChr 1: 149.71 – 149.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.[6]

Interactions

PLA2G4A has been shown to interact with histone acetyltransferase KAT5.[7]

Clinical significance

Mutations in this gene have been associated with multifocal stenosing ulceration of the small intestine.[8]

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.