PLA2G5

Calcium-dependent phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G5 gene.^[5][6][7]

PLA2G5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GHN
Identifiers
Aliases	PLA2G5, FRFB, GV-PLA2, PLA2-10, hVPLA(2), phospholipase A2 group V
External IDs	OMIM: 601192; MGI: 101899; HomoloGene: 716; GeneCards: PLA2G5; OMA:PLA2G5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 20,028,179 bp[1] End 20,091,911 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 70.57 cM Start 138,526,555 bp[2] End 138,590,793 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle of heart apex of heart right coronary artery left ventricle left ovary right ovary left coronary artery right ventricle cardiac muscle tissue of right atrium retinal pigment epithelium Top expressed in basal plate neural layer of retina molar epithelium of lens vestibular membrane of cochlear duct intercostal muscle retinal pigment epithelium iris trachea utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding heparin binding calcium-dependent phospholipase A2 activity metal ion binding hydrolase activity phospholipase A2 activity phospholipid binding Cellular component Golgi apparatus plasma membrane extracellular region perinuclear region of cytoplasm cell surface Biological process phosphatidic acid biosynthetic process response to cytokine phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling lipid metabolism platelet activating factor biosynthetic process phosphatidylinositol acyl-chain remodeling lipid catabolic process positive regulation of phospholipase activity phosphatidylglycerol acyl-chain remodeling positive regulation of ERK1 and ERK2 cascade response to cAMP leukotriene biosynthetic process phosphatidylcholine acyl-chain remodeling arachidonic acid secretion phospholipid metabolic process low-density lipoprotein particle remodeling regulation of macrophage activation negative regulation of inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5322 18784 Ensembl ENSG00000127472 ENSMUSG00000041193 UniProt P39877 P97391 RefSeq (mRNA) NM_000929 NM_001122954 NM_011110 RefSeq (protein) NP_000920 NP_001116426 NP_035240 Location (UCSC) Chr 1: 20.03 – 20.09 Mb Chr 4: 138.53 – 138.59 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the secretory phospholipase A₂ family. It is located in a tightly-linked cluster of secretory phospholipase A₂ genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.^[7]

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