PLAG1

Zinc finger protein PLAG1 is a protein that in humans is encoded by the PLAG1 gene.^[5][6]

PLAG1
Identifiers
Aliases	PLAG1, PSA, SGPA, ZNF912, PLAG1 zinc finger, SRS4
External IDs	OMIM: 603026; MGI: 1891916; HomoloGene: 1993; GeneCards: PLAG1; OMA:PLAG1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q12.1 Start 56,160,909 bp[1] End 56,211,324 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A1 Start 3,900,996 bp[2] End 3,938,423 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte amniotic fluid testicle stromal cell of endometrium gonad epithelium of nasopharynx right uterine tube retinal pigment epithelium ventricular zone palpebral conjunctiva Top expressed in zygote secondary oocyte genital tubercle tail of embryo female urethra epithelium of seminiferous tubule of testis primary oocyte male urethra photoreceptor layer of retina theca folliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nuclear speck Biological process prostate gland growth gland morphogenesis positive regulation of gene expression positive regulation of glial cell proliferation regulation of transcription, DNA-templated organ growth negative regulation of gene expression positive regulation of transcription by RNA polymerase II multicellular organism growth transcription, DNA-templated transcription by RNA polymerase II apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5324 56711 Ensembl ENSG00000181690 ENSMUSG00000003282 UniProt Q6DJT9 Q9QYE0 RefSeq (mRNA) NM_001114634 NM_001114635 NM_002655 NM_019969 RefSeq (protein) NP_001108106 NP_001108107 NP_002646 NP_064353 Location (UCSC) Chr 8: 56.16 – 56.21 Mb Chr 4: 3.9 – 3.94 Mb PubMed search [3] [4]
Wikidata
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Function

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas.^[6]

Interactions

PLAG1 has been shown to interact with Karyopherin alpha 2.^[7]