PLAGL1

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.^[5][6][7]

PLAGL1
Identifiers
Aliases	PLAGL1, LOT1, ZAC, ZAC1, PLAG1 like zinc finger 1
External IDs	OMIM: 603044; MGI: 1100874; HomoloGene: 31401; GeneCards: PLAGL1; OMA:PLAGL1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.2 Start 143,940,300 bp[1] End 144,064,599 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A2|10 4.72 cM Start 13,060,504 bp[2] End 13,131,694 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of hip placenta right adrenal cortex tibia cartilage tissue pituitary gland synovial joint human penis Descending thoracic aorta skin of thigh Top expressed in efferent ductule dermis human fetus Gonadal ridge atrium internal carotid artery median eminence umbilical cord left lung lobe abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription activator activity, RNA polymerase II-specific nucleic acid binding metal ion binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component Golgi apparatus intracellular membrane-bounded organelle nucleus nucleoplasm nuclear body Biological process cell differentiation regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5325 22634 Ensembl ENSG00000118495 ENSMUSG00000019817 UniProt Q9UM63 n/a RefSeq (mRNA) NM_006718 NM_001080951 NM_001080952 NM_001080953 NM_001080954 NM_001080955 NM_001080956 NM_001289037 NM_001289038 NM_001289039 NM_001289040 NM_001289041 NM_001289042 NM_001289043 NM_001289044 NM_001289045 NM_001289046 NM_001289047 NM_001289048 NM_001289049 NM_002656 NM_001317156 NM_001317157 NM_001317158 NM_001317159 NM_001317160 NM_001317161 NM_001317162 NM_009538 RefSeq (protein) NP_001074420 NP_001074421 NP_001074422 NP_001074423 NP_001074424 NP_001074425 NP_001275966 NP_001275967 NP_001275968 NP_001275969 NP_001275970 NP_001275971 NP_001275972 NP_001275973 NP_001275974 NP_001275975 NP_001275976 NP_001275977 NP_001275978 NP_001304085 NP_001304086 NP_001304087 NP_001304088 NP_001304089 NP_001304090 NP_001304091 NP_006709 n/a Location (UCSC) Chr 6: 143.94 – 144.06 Mb Chr 10: 13.06 – 13.13 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.^[7]

Interactions

PLAGL1 has been shown to interact with P53.^[8]