PLAGL2

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene.^[5][6][7]

PLAGL2
Identifiers
Aliases	PLAGL2, ZNF900, PLAG1 like zinc finger 2
External IDs	OMIM: 604866; MGI: 1933165; HomoloGene: 1994; GeneCards: PLAGL2; OMA:PLAGL2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 32,192,504 bp[1] End 32,207,743 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 153,069,679 bp[2] End 153,083,346 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm monocyte secondary oocyte granulocyte testicle gonad amniotic fluid buccal mucosa cell right testis left testis Top expressed in epithelium of small intestine tail of embryo genital tubercle fetal liver hematopoietic progenitor cell migratory enteric neural crest cell lens maxillary prominence mandibular prominence ileum inner renal medulla More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated chylomicron assembly positive regulation of transcription by RNA polymerase II transcription, DNA-templated lipid metabolism positive regulation of intrinsic apoptotic signaling pathway post-embryonic development transcription by RNA polymerase II apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5326 54711 Ensembl ENSG00000126003 ENSMUSG00000051413 UniProt Q9UPG8 Q925T4 RefSeq (mRNA) NM_002657 NM_018807 RefSeq (protein) NP_002648 NP_061277 Location (UCSC) Chr 20: 32.19 – 32.21 Mb Chr 2: 153.07 – 153.08 Mb PubMed search [3] [4]
Wikidata
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Zinc finger protein PLAGL2 is a zinc finger protein that recognizes DNA and/or RNA.^[7]

The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors.^[8]