PLAT domain

In molecular biology the PLAT domain is a protein domain that is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain^[2] or LH2 (Lipoxygenase homology) domain.^[3] The known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association.

PLAT/LH2 domain
Structure of the lipase-procolipase complex.[1]
Identifiers
Symbol	PLAT
Pfam	PF01477
InterPro	IPR001024
SMART	SM00308
PROSITE	PDOC50095
SCOP2	1lpa / SCOPe / SUPFAM
OPM superfamily	221
OPM protein	3swz
CDD	cd00113
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

This domain forms a beta-sandwich composed of two β-sheets of four β-strands each.^[2][4][5]

Human proteins containing this domain

ALOX12; ALOX12B; ALOX12P2; ALOX15; ALOX15B; ALOX5; ALOXE3; LIPC; LIPG; LOXHD1; LPL; PKD1; PKD1L1; PKD1L2; PKD1L3; PKDREJ; PNLIP; PNLIPRP1; PNLIPRP2; PNLIPRP3; RAB6IP1;