PLCD1

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene.^[5][6] PLCd1 is essential to maintain homeostasis of the skin.

PLCD1
Identifiers
Aliases	PLCD1, NDNC3, PLC-III, phospholipase C delta 1
External IDs	OMIM: 602142; MGI: 97614; HomoloGene: 21252; GeneCards: PLCD1; OMA:PLCD1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 38,007,496 bp[1] End 38,029,642 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 118,900,595 bp[2] End 118,922,570 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb mucosa of transverse colon thoracic diaphragm right testis left testis dorsal motor nucleus of vagus nerve Descending thoracic aorta inferior olivary nucleus ascending aorta gingival epithelium Top expressed in esophagus calvaria lip transitional epithelium of urinary bladder membranous bone body of femur ascending aorta corneal stroma Dermatocranium ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activating protein binding calcium ion binding phosphatidylinositol phosphate binding phosphatidylserine binding signal transducer activity metal ion binding phosphatidic acid binding phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding protein binding Cellular component cytoplasm cytosol plasma membrane extracellular exosome Biological process intracellular signal transduction lipid metabolism labyrinthine layer blood vessel development inositol phosphate metabolic process lipid catabolic process regulation of cell population proliferation angiogenesis phospholipid metabolic process signal transduction inositol trisphosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5333 18799 Ensembl ENSG00000187091 ENSMUSG00000010660 UniProt P51178 Q8R3B1 RefSeq (mRNA) NM_001130964 NM_006225 NM_001293648 NM_019676 RefSeq (protein) NP_001124436 NP_006216 NP_001280577 NP_062650 Location (UCSC) Chr 3: 38.01 – 38.03 Mb Chr 9: 118.9 – 118.92 Mb PubMed search [3] [4]
Wikidata
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See also

Phospholipase C