PLCG2

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.^[5][6]

PLCG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K2J, 2W2W, 2W2X
Identifiers
Aliases	PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2, phospholipase C gamma 2
External IDs	OMIM: 600220; MGI: 97616; HomoloGene: 55671; GeneCards: PLCG2; OMA:PLCG2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.3 Start 81,739,097 bp[1] End 81,962,685 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E1|8 64.26 cM Start 118,225,030 bp[2] End 118,361,881 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus bone marrow cells blood metanephric glomerulus epithelium of nasopharynx spleen granulocyte endothelial cell appendix kidney tubule Top expressed in basilar part of occipital bone granulocyte tibiofemoral joint mesenteric lymph nodes spleen bone marrow blood sphenoid bone external carotid artery internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein binding phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol phospholipase C activity phosphotyrosine residue binding Cellular component cytosol plasma membrane extracellular exosome Biological process B cell receptor signaling pathway release of sequestered calcium ion into cytosol intracellular signal transduction inositol trisphosphate biosynthetic process Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of receptor internalization lipid metabolism stimulatory C-type lectin receptor signaling pathway inositol phosphate metabolic process Wnt signaling pathway platelet activation Fc-epsilon receptor signaling pathway lipid catabolic process follicular B cell differentiation response to lipopolysaccharide phospholipid catabolic process regulation of gene expression phosphatidylinositol biosynthetic process negative regulation of programmed cell death B cell differentiation T cell receptor signaling pathway activation of store-operated calcium channel activity positive regulation of type I interferon production calcium-mediated signaling signal transduction phosphatidylinositol-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5336 234779 Ensembl ENSG00000197943 ENSMUSG00000034330 UniProt P16885 Q8CIH5 RefSeq (mRNA) NM_002661 NM_172285 RefSeq (protein) NP_002652 NP_758489 Location (UCSC) Chr 16: 81.74 – 81.96 Mb Chr 8: 118.23 – 118.36 Mb PubMed search [3] [4]
Wikidata
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Function

From OMIM as of March 24, 2020:^[7]

Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.

Interactions

PLCG2 has been shown to interact with:

• Bruton's tyrosine kinase,^[8][9]
• GAB2,^[10]
• LYN,^[8][11]
• PTPN11,^[10] and
• SHC1^[10][12]