PLEK2

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.^[5][6][7] The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.^[8]

PLEK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X1G
Identifiers
Aliases	PLEK2, pleckstrin 2
External IDs	OMIM: 608007; MGI: 1351466; HomoloGene: 8447; GeneCards: PLEK2; OMA:PLEK2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.3-q24.1 Start 67,386,984 bp[1] End 67,412,167 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 78,935,465 bp[2] End 78,953,738 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte mucosa of transverse colon right adrenal cortex gingival epithelium left adrenal gland left adrenal cortex corpus epididymis rectum jejunal mucosa Top expressed in Paneth cell molar fetal liver hematopoietic progenitor cell lumbar spinal ganglion gastric mucosa mucous cell of stomach epithelium of stomach pyloric antrum duodenum lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-3-phosphate binding Cellular component cytoplasm plasma membrane cell projection lamellipodium membrane cytoskeleton membrane Biological process intracellular signal transduction actin cytoskeleton organization positive regulation of cell projection organization actin cytoskeleton reorganization positive regulation of plasma membrane bounded cell projection assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26499 27260 Ensembl ENSG00000100558 ENSMUSG00000021118 UniProt Q9NYT0 Q9WV52 RefSeq (mRNA) NM_016445 NM_013738 RefSeq (protein) NP_057529 NP_038766 Location (UCSC) Chr 14: 67.39 – 67.41 Mb Chr 12: 78.94 – 78.95 Mb PubMed search [3] [4]
Wikidata
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