PLEKHO1

Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.^[5][6]

PLEKHO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AA1
Identifiers
Aliases	PLEKHO1, CKIP-1, OC120, CKIP1, JBP, pleckstrin homology domain containing O1
External IDs	OMIM: 608335; MGI: 1914470; HomoloGene: 9448; GeneCards: PLEKHO1; OMA:PLEKHO1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 150,149,183 bp[1] End 150,164,720 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,895,741 bp[2] End 95,903,313 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte gastric mucosa granulocyte muscle layer of sigmoid colon left testis right testis popliteal artery tibial arteries right coronary artery ganglionic eminence Top expressed in genital tubercle tail of embryo ventricular zone decidua gastrula ganglionic eminence superior frontal gyrus primary visual cortex cerebellar cortex internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm ruffle membrane plasma membrane muscle cell projection membrane membrane nucleus Biological process myoblast migration myoblast fusion lamellipodium morphogenesis regulation of cell shape Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51177 67220 Ensembl ENSG00000023902 ENSMUSG00000015745 UniProt Q53GL0 Q9JIY0 RefSeq (mRNA) NM_016274 NM_001304722 NM_001304723 NM_001304724 NM_023320 RefSeq (protein) NP_001291651 NP_001291652 NP_001291653 NP_057358 NP_075809 Location (UCSC) Chr 1: 150.15 – 150.16 Mb Chr 3: 95.9 – 95.9 Mb PubMed search [3] [4]
Wikidata
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Interactions

PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1^[5] and SMURF1.^[7]