PLK2

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.^[5]

PLK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4I5M, 4I5P, 4I6B, 4I6F, 4I6H, 4RS6, 4XB0
Identifiers
Aliases	PLK2, SNK, hPlk2, hSNK, polo like kinase 2
External IDs	OMIM: 607023; MGI: 1099790; HomoloGene: 21317; GeneCards: PLK2; OMA:PLK2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 58,453,982 bp[1] End 58,460,139 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.1 Start 110,531,580 bp[2] End 110,537,378 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen apex of heart canal of the cervix ectocervix islet of Langerhans epithelium of colon skin of abdomen Achilles tendon gallbladder tibial nerve Top expressed in CA3 field Region I of hippocampus proper perirhinal cortex entorhinal cortex primary motor cortex primary visual cortex olfactory tubercle choroid plexus of fourth ventricle superior frontal gyrus left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein-containing complex binding signal transducer activity ATP-dependent protein binding kinase activity protein binding ATP binding protein serine/threonine kinase activity Cellular component cytoplasm centrosome cell projection intracellular anatomical structure dendrite centriole chromatin cytoskeleton cytosol Biological process positive regulation of protein catabolic process positive regulation of autophagy phosphorylation mitotic cell cycle checkpoint signaling G1 phase mitotic spindle organization Rap protein signal transduction regulation of centriole replication negative regulation of apoptotic process memory regulation of synaptic plasticity protein phosphorylation peptidyl-serine phosphorylation long-term depression mitotic cell cycle positive regulation of I-kappaB kinase/NF-kappaB signaling Ras protein signal transduction positive regulation of protein binding negative regulation of dendritic spine development positive regulation of proteasomal ubiquitin-dependent protein catabolic process long-term potentiation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10769 20620 Ensembl ENSG00000145632 ENSMUSG00000021701 UniProt Q9NYY3 P53351 RefSeq (mRNA) NM_006622 NM_001252226 NM_152804 RefSeq (protein) NP_001239155 NP_006613 NP_690017 Location (UCSC) Chr 5: 58.45 – 58.46 Mb Chr 13: 110.53 – 110.54 Mb PubMed search [3] [4]
Wikidata
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Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. [supplied by OMIM]^[5]