PLS3

Plastin-3 is a highly conserved protein that in humans is encoded by the PLS3 gene on the X chromosome.^[5][6]

PLS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AOA, 1WJO
Identifiers
Aliases	PLS3, BMND18, T-plastin, plastin 3
External IDs	OMIM: 300131; MGI: 104807; HomoloGene: 128200; GeneCards: PLS3; OMA:PLS3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq23 Start 115,561,174 bp[1] End 115,650,861 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 74,829,260 bp[2] End 74,918,788 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon visceral pleura parietal pleura skin of hip amniotic fluid Descending thoracic aorta ascending aorta right coronary artery oral cavity skin of thigh Top expressed in tunica media of zone of aorta subiculum ascending aorta conjunctival fornix efferent ductule pontine nuclei umbilical cord carotid body molar mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding actin binding metal ion binding actin filament binding Cellular component cytoplasm cytosol actin filament plasma membrane actin filament bundle Biological process bone development actin filament bundle assembly actin filament network formation actin crosslink formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5358 102866 Ensembl ENSG00000102024 ENSMUSG00000016382 UniProt P13797 Q99K51 RefSeq (mRNA) NM_001136025 NM_001172335 NM_001282337 NM_001282338 NM_005032 NM_001166453 NM_001166454 NM_145629 NM_001346519 NM_001346520 RefSeq (protein) NP_001129497 NP_001165806 NP_001269266 NP_001269267 NP_005023 NP_001159925 NP_001159926 NP_001333448 NP_001333449 NP_663604 Location (UCSC) Chr X: 115.56 – 115.65 Mb Chr X: 74.83 – 74.92 Mb PubMed search [3] [4]
Wikidata
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Function

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N-terminus.^[6]

Clinical significance

Defects in PLS3 are associated with osteoporosis and bone fracture in humans and in knockout zebrafish.^[7]