Phospholipid transfer protein

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.

PLTP
Identifiers
Aliases	PLTP, BPIFE, HDLCQ9, phospholipid transfer protein
External IDs	MGI: 103151; HomoloGene: 4536; GeneCards: PLTP; OMA:PLTP - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,898,621 bp[1] End 45,912,155 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 85.27 cM Start 164,681,438 bp[2] End 164,699,631 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery right adrenal cortex gastric mucosa gallbladder right ovary body of pancreas canal of the cervix left adrenal gland left ovary left coronary artery Top expressed in retinal pigment epithelium right lung lobe habenula molar left lung left lung lobe choroid plexus of fourth ventricle cerebellar vermis lobe of cerebellum dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding lipid transporter activity phospholipid transporter activity phosphatidylethanolamine binding phosphatidylcholine transporter activity diacylglycerol binding phosphatidylcholine binding phosphatidic acid binding ceramide binding phosphatidylglycerol binding phosphatidylethanolamine transfer activity phosphatidic acid transfer activity Cellular component extracellular region extracellular space high-density lipoprotein particle Biological process high-density lipoprotein particle remodeling flagellated sperm motility positive regulation of cholesterol efflux vitamin E biosynthetic process lipid metabolism transport lipid transport phospholipid transport ceramide transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5360 18830 Ensembl ENSG00000100979 ENSMUSG00000017754 UniProt P55058 P55065 RefSeq (mRNA) NM_182676 NM_001242920 NM_001242921 NM_006227 NM_011125 RefSeq (protein) NP_001229849 NP_001229850 NP_006218 NP_872617 NP_035255 Location (UCSC) Chr 20: 45.9 – 45.91 Mb Chr 2: 164.68 – 164.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

PLTP has been shown to interact with Apolipoprotein A1^[6] and APOA2.^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Statin pathway edit]]

Statin pathway edit

1. The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".