Top Qs
Timeline
Chat
Perspective

PLXNA2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

PLXNA2
Remove ads

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.[5][6]

Quick Facts Available structures, PDB ...

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.[6]

In some studies, the PLXNA2 gene is associated with schizophrenia.[7] and anxiety. PLXNA2 is a candidate gene for intellectual disability and possibly facial dysmorphism and congenital heart disease[8][9]

Remove ads

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads