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PLXNA2
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.[5][6]
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.[6]
In some studies, the PLXNA2 gene is associated with schizophrenia.[7] and anxiety. PLXNA2 is a candidate gene for intellectual disability and possibly facial dysmorphism and congenital heart disease[8][9]
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