PMM1

Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.^[5][6][7]

PMM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FUC, 2FUE
Identifiers
Aliases	PMM1, Sec53, phosphomannomutase 1, PMMH-22, PMM 1
External IDs	OMIM: 601786; MGI: 1353418; HomoloGene: 90898; GeneCards: PMM1; OMA:PMM1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 41,576,900 bp[1] End 41,589,871 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 81,835,309 bp[2] End 81,845,131 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon body of stomach right lobe of liver nucleus accumbens right frontal lobe right adrenal gland right lung left adrenal gland right adrenal cortex cingulate gyrus Top expressed in morula morula neural layer of retina dentate gyrus of hippocampal formation granule cell superior frontal gyrus cerebellar cortex primary visual cortex lateral hypothalamus lateral geniculate nucleus hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphomannomutase activity isomerase activity protein binding metal ion binding Cellular component cytoplasm soma cytosol Biological process mannose metabolic process protein N-linked glycosylation protein targeting to ER GDP-mannose biosynthetic process cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5372 29858 Ensembl ENSG00000100417 ENSMUSG00000022474 UniProt Q92871 O35621 RefSeq (mRNA) NM_002676 NM_001282040 NM_001282041 NM_013872 RefSeq (protein) NP_002667 NP_001268969 NP_001268970 NP_038900 Location (UCSC) Chr 22: 41.58 – 41.59 Mb Chr 15: 81.84 – 81.85 Mb PubMed search [3] [4]
Wikidata
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Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of Glycosylphosphatidylinositol (GPI) anchored proteins.^[7]

This enzyme has been extracted from the venom of the wasp species Polistes major major.^[8]