PNRC1

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.^[5][6]

PNRC1
Identifiers
Aliases	PNRC1, B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDs	OMIM: 606714; MGI: 1917838; HomoloGene: 4960; GeneCards: PNRC1; OMA:PNRC1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,080,751 bp[1] End 89,085,160 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 33,245,423 bp[2] End 33,290,163 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastric mucosa left uterine tube gastrocnemius muscle left ovary muscle of thigh right ovary tibial arteries epithelium of colon gallbladder Top expressed in left lung lobe medial ganglionic eminence granulocyte lymph node mesenteric lymph nodes lacrimal gland molar thoracic diaphragm submandibular gland digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component P-body nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-independent decapping of nuclear-transcribed mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10957 108767 Ensembl ENSG00000146278 ENSMUSG00000040128 UniProt Q12796 Q49A59 Q3TWH3 RefSeq (mRNA) NM_006813 NM_001033225 RefSeq (protein) NP_006804 NP_001028397 Location (UCSC) Chr 6: 89.08 – 89.09 Mb Chr 4: 33.25 – 33.29 Mb PubMed search [3] [4]
Wikidata
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Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.^[7][8] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.^[8]