POLD2

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.^[5][6] It is a component of the DNA polymerase delta complex.

POLD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E0J
Identifiers
Aliases	POLD2, DNA polymerase delta 2, accessory subunit
External IDs	OMIM: 600815; MGI: 1097163; HomoloGene: 4538; GeneCards: POLD2; OMA:POLD2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,114,681 bp[1] End 44,124,358 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 5,822,180 bp[2] End 5,828,292 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube apex of heart ventricular zone right lobe of liver right auricle of heart body of pancreas left ovary right hemisphere of cerebellum skin of abdomen muscle of thigh Top expressed in yolk sac genital tubercle ventricular zone internal carotid artery epiblast embryo mandibular prominence maxillary prominence external carotid artery embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding DNA-directed DNA polymerase activity Cellular component nucleoplasm nucleus delta DNA polymerase complex Biological process nucleotide-excision repair, DNA gap filling DNA replication translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision telomere maintenance nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair DNA strand elongation involved in DNA replication cellular response to DNA damage stimulus telomere maintenance via semi-conservative replication DNA mismatch repair DNA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5425 18972 Ensembl ENSG00000106628 ENSMUSG00000020471 UniProt P49005 O35654 RefSeq (mRNA) NM_001127218 NM_001256879 NM_006230 NM_008894 NM_001361942 RefSeq (protein) NP_001120690 NP_001243808 NP_006221 NP_032920 NP_001348871 Location (UCSC) Chr 7: 44.11 – 44.12 Mb Chr 11: 5.82 – 5.83 Mb PubMed search [3] [4]
Wikidata
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Interactions

POLD2 has been shown to interact with PCNA.^[7]