POLD3

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene.^[5][6] It is a component of the DNA polymerase delta complex.

POLD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U76, 3E0J, 2N1G
Identifiers
Aliases	POLD3, P66, P68, PPP1R128, polymerase (DNA) delta 3, accessory subunit, DNA polymerase delta 3, accessory subunit
External IDs	OMIM: 611415; MGI: 1915217; HomoloGene: 38202; GeneCards: POLD3; OMA:POLD3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 74,493,851 bp[1] End 74,669,117 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 99,731,318 bp[2] End 99,770,772 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone testicle sperm ganglionic eminence rectum gonad monocyte kidney tubule bronchial epithelial cell Top expressed in secondary oocyte zygote tail of embryo primary oocyte genital tubercle spermatid morula somite primitive streak seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding DNA-directed DNA polymerase activity Cellular component delta DNA polymerase complex nucleus nucleoplasm cytoplasm Biological process nucleotide-excision repair, DNA gap filling DNA synthesis involved in DNA repair DNA replication translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision telomere maintenance DNA-dependent DNA replication nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair cellular response to DNA damage stimulus telomere maintenance via semi-conservative replication DNA mismatch repair DNA strand elongation involved in DNA replication DNA synthesis involved in UV-damage excision repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10714 67967 Ensembl ENSG00000077514 ENSMUSG00000030726 UniProt Q15054 Q9EQ28 RefSeq (mRNA) NM_006591 NM_001363597 NM_133692 NM_001368380 RefSeq (protein) NP_006582 NP_001350526 NP_598453 NP_001355309 Location (UCSC) Chr 11: 74.49 – 74.67 Mb Chr 7: 99.73 – 99.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POLD3 has been shown to interact with PCNA.^[7][8]