POLDIP2

Polymerase delta-interacting protein 2 also known as Polymerase delta-interacting protein of 38 kDa (PDIP38) is encoded by the POLDIP2 gene in humans.^[5][6]

POLDIP2
Identifiers
Aliases	POLDIP2, PDIP38, POLD4, p38, polymerase (DNA) delta interacting protein 2, DNA polymerase delta interacting protein 2
External IDs	OMIM: 611519; MGI: 1915061; HomoloGene: 9201; GeneCards: POLDIP2; OMA:POLDIP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,346,633 bp[1] End 28,357,527 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 78,403,019 bp[2] End 78,413,562 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh right adrenal gland right adrenal cortex left adrenal gland apex of heart left adrenal cortex right lobe of liver left ventricle right auricle of heart Top expressed in spermatocyte spermatid right kidney brown adipose tissue muscle of thigh vastus lateralis muscle proximal tubule tibialis anterior muscle ventricular zone triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding Cellular component mitochondrial nucleoid mitochondrion nucleus Biological process mitochondrion morphogenesis negative regulation of macroautophagy positive regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26073 67811 Ensembl ENSG00000004142 ENSMUSG00000001100 UniProt Q9Y2S7 Q91VA6 RefSeq (mRNA) NM_015584 NM_001290145 NM_026389 RefSeq (protein) NP_001277074 NP_056399 NP_080665 Location (UCSC) Chr 17: 28.35 – 28.36 Mb Chr 11: 78.4 – 78.41 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).^[6] POLDIP2 / PDIP38 is a moonlighting protein that has been identified in both the nucleus ^[7] and the mitochondrion ^[8][9]

Interactions

In the nucleus, POLDIP2 has been shown to interact with PCNA,^[5] while in the mitochondrion POLDIP2 has been shown to interact with proteins constituting the mitochondrial DNA nucleoid ^[10] and the AAA+ protease CLPXP ^[9][11] where it modulates both the specificity and stability of this proteolytic machine.