POLE3

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.^[5][6][7]

POLE3
Identifiers
Aliases	POLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2
External IDs	OMIM: 607267; MGI: 1933378; HomoloGene: 9694; GeneCards: POLE3; OMA:POLE3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 113,407,235 bp[1] End 113,410,675 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B3 Start 62,440,886 bp[2] End 62,443,305 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad gastrocnemius muscle granulocyte monocyte human penis ganglionic eminence muscle of thigh rectum ventricular zone bone marrow Top expressed in spermatocyte ventricular zone yolk sac secondary oocyte zygote fetal liver hematopoietic progenitor cell seminiferous tubule morula molar mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity protein binding protein heterodimerization activity histone acetyltransferase activity Cellular component epsilon DNA polymerase complex nucleus nucleoplasm Biological process DNA replication histone H3 acetylation DNA biosynthetic process G1/S transition of mitotic cell cycle cellular response to DNA damage stimulus CENP-A containing chromatin assembly cellular response to gamma radiation DNA replication initiation telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54107 59001 Ensembl ENSG00000148229 ENSMUSG00000028394 UniProt Q9NRF9 Q9JKP7 RefSeq (mRNA) NM_001278255 NM_017443 NM_021498 RefSeq (protein) NP_001265184 NP_059139 NP_067473 Location (UCSC) Chr 9: 113.41 – 113.41 Mb Chr 4: 62.44 – 62.44 Mb PubMed search [3] [4]
Wikidata
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POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]^[7]

Interactions

POLE3 has been shown to interact with SMARCA5.^[6]