POLE4

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.^[5]

POLE4
Identifiers
Aliases	POLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDs	OMIM: 607269; MGI: 1914229; HomoloGene: 41339; GeneCards: POLE4; OMA:POLE4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 74,958,643 bp[1] End 74,970,128 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 82,595,973 bp[2] End 82,682,346 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte cingulate gyrus anterior cingulate cortex mucosa of transverse colon right adrenal cortex popliteal artery tibial arteries monocyte left adrenal gland gastrocnemius muscle Top expressed in zygote secondary oocyte primary oocyte yolk sac retinal pigment epithelium ciliary body right kidney ventricular zone embryo iris More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity protein binding protein heterodimerization activity Cellular component epsilon DNA polymerase complex nucleus nucleoplasm Biological process histone H3 acetylation DNA biosynthetic process G1/S transition of mitotic cell cycle DNA replication initiation telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56655 66979 Ensembl ENSG00000115350 ENSMUSG00000030042 UniProt Q9NR33 Q9CQ36 RefSeq (mRNA) NM_019896 NM_025882 NM_001370295 RefSeq (protein) NP_063949 NP_080158 NP_001357224 Location (UCSC) Chr 2: 74.96 – 74.97 Mb Chr 6: 82.6 – 82.68 Mb PubMed search [3] [4]
Wikidata
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Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.^[5]