POLR2F

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.^[5]

POLR2F
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QKL, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2F, HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15, polymerase (RNA) II subunit F, RNA polymerase II subunit F, RNA polymerase II, I and III subunit F
External IDs	OMIM: 604414; MGI: 1349393; HomoloGene: 7178; GeneCards: POLR2F; OMA:POLR2F - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,952,607 bp[1] End 38,041,915 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.7 cM Start 79,025,209 bp[2] End 79,035,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment tibial nerve tendon of biceps brachii apex of heart right lobe of liver right auricle of heart amygdala left ventricle anterior pituitary ganglionic eminence Top expressed in yolk sac morula morula otic vesicle medial ganglionic eminence endothelial cell of lymphatic vessel embryo embryo ventricular zone vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II activity RNA polymerase III activity DNA-directed 5'-3' RNA polymerase activity RNA polymerase I activity Cellular component cytosol nucleoplasm RNA polymerase I complex RNA polymerase III complex RNA polymerase II, core complex nucleus fibrillar center Biological process termination of RNA polymerase I transcription mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway transcription by RNA polymerase III RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5435 69833 Ensembl ENSG00000100142 ENSMUSG00000033020 UniProt P61218 P61219 RefSeq (mRNA) NM_001301129 NM_001301130 NM_001301131 NM_021974 NM_001363825 NM_027231 RefSeq (protein) NP_001288058 NP_001288059 NP_001288060 NP_068809 NP_001350754 NP_081507 Location (UCSC) Chr 22: 37.95 – 38.04 Mb Chr 15: 79.03 – 79.04 Mb PubMed search [3] [4]
Wikidata
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This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.^[6]

Interactions

POLR2F has been shown to interact with POLR2C.^[7]

See also

• RNA polymerase II