POLR2J

DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the POLR2J gene.

POLR2J
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2J, POLR2J1, RPB11, RPB11A, RPB11m, hRPB14, polymerase (RNA) II subunit J, RNA polymerase II subunit J
External IDs	OMIM: 604150; MGI: 109582; HomoloGene: 4542; GeneCards: POLR2J; OMA:POLR2J - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 102,473,128 bp[1] End 102,478,922 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 136,145,485 bp[2] End 136,151,801 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh apex of heart left ventricle right auricle of heart left adrenal cortex mucosa of transverse colon substantia nigra putamen amygdala Top expressed in yolk sac zygote embryo morula embryo otic placode internal carotid artery ventricular zone primary oocyte epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding LRR domain binding protein dimerization activity DNA-directed 5'-3' RNA polymerase activity protein binding RNA polymerase II activity Cellular component nucleoplasm nucleus RNA polymerase II, core complex Biological process mRNA splicing, via spliceosome transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway RNA metabolic process regulation of gene silencing by miRNA transcription by RNA polymerase II transcription, DNA-templated somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5439 20022 Ensembl ENSG00000005075 ENSMUSG00000039771 UniProt P52435 O08740 RefSeq (mRNA) NM_006234 NM_001371100 NM_001393919 NM_011293 RefSeq (protein) NP_006225 NP_001358029 n/a Location (UCSC) Chr 7: 102.47 – 102.48 Mb Chr 5: 136.15 – 136.15 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13.^[5]

Interactions

POLR2J has been shown to interact with:

• Apoptosis antagonizing transcription factor,^[6]
• POLR2C,^[7][8] and
• SATB1.^[9]