POLR2K

DNA-directed RNA polymerases I, II, and III subunit RPABC4 is a protein that in humans is encoded by the POLR2K gene.

POLR2K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2K, ABC10-alpha, RPABC4, RPB10alpha, RPB12, RPB7.0, hRPB7.0, hsRPB10a, polymerase (RNA) II subunit K, RNA polymerase II subunit K, RNA polymerase II, I and III subunit K
External IDs	OMIM: 606033; MGI: 102725; HomoloGene: 86049; GeneCards: POLR2K; OMA:POLR2K - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 100,150,623 bp[1] End 100,154,003 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 36,174,156 bp[2] End 36,177,156 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans Achilles tendon tibial arteries C1 segment Brodmann area 9 left adrenal gland right adrenal gland rectum ganglionic eminence right adrenal cortex Top expressed in quadriceps femoris muscle morula neural tube yolk sac ventricular zone ganglionic eminence embryo proximal tubule embryo blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding RNA polymerase II activity metal ion binding RNA polymerase III activity DNA-directed 5'-3' RNA polymerase activity RNA polymerase I activity Cellular component cytosol nucleoplasm RNA polymerase I complex RNA polymerase III complex RNA polymerase II, core complex nucleus Biological process termination of RNA polymerase I transcription mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation regulation of transcription by RNA polymerase I transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter transcription by RNA polymerase III snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5440 17749 Ensembl ENSG00000147669 ENSMUSG00000045996 UniProt P53803 Q63871 RefSeq (mRNA) NM_005034 NM_001039368 NM_023127 RefSeq (protein) NP_005025 NP_001034457 NP_075616 Location (UCSC) Chr 8: 100.15 – 100.15 Mb Chr 15: 36.17 – 36.18 Mb PubMed search [3] [4]
Wikidata
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This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases.^[5]

Interactions

POLR2K has been shown to interact with POLR2C.^[6]