PPAP2A

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.^[5][6]

PLPP1
Identifiers
Aliases	PLPP1, LLP1a, LPP1, PAP-2a, PAP2, PPAP2A, phospholipid phosphatase 1
External IDs	OMIM: 607124; MGI: 108412; HomoloGene: 7484; GeneCards: PLPP1; OMA:PLPP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 55,424,854 bp[1] End 55,534,969 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 112,937,326 bp[2] End 113,004,428 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua gallbladder prostate glomerulus metanephric glomerulus left coronary artery right coronary artery mucosa of urinary bladder abdominal fat pericardium Top expressed in seminal vesicula endothelial cell of lymphatic vessel gastrula decidua ankle right lung lobe adrenal gland semi-lunar valve molar carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidate phosphatase activity hydrolase activity sphingosine-1-phosphate phosphatase activity lipid phosphatase activity phosphatase activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process androgen receptor signaling pathway phospholipid metabolic process regulation of lipid metabolic process protein dephosphorylation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular steroid hormone receptor signaling pathway sphingolipid biosynthetic process germ cell migration negative regulation of cell population proliferation lipid metabolism phospholipid dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8611 19012 Ensembl ENSG00000067113 ENSMUSG00000021759 UniProt O14494 Q61469 RefSeq (mRNA) NM_003711 NM_176895 NM_008247 NM_008903 RefSeq (protein) NP_003702 NP_795714 NP_032273 NP_032929 Location (UCSC) Chr 5: 55.42 – 55.53 Mb Chr 13: 112.94 – 113 Mb PubMed search [3] [4]
Wikidata
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Function

Lipid phosphate phosphohydrolase 1 is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.^[6]