PPARGC1B

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.^[5][6][7]

PPARGC1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SP6
Identifiers
Aliases	PPARGC1B, ERRL1, PERC, PGC-1(beta), PGC1B, PPARG coactivator 1 beta
External IDs	OMIM: 608886; MGI: 2444934; HomoloGene: 15776; GeneCards: PPARGC1B; OMA:PPARGC1B - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 149,730,298 bp[1] End 149,855,022 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 61,431,207 bp[2] End 61,533,502 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte germinal epithelium jejunal mucosa duodenum testicle Brodmann area 23 gonad apex of heart monocyte Top expressed in right ventricle brown adipose tissue ciliary body cerebellar vermis epithelium of stomach lobe of cerebellum left colon crypt of lieberkuhn of small intestine olfactory tubercle pyloric antrum More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coregulator activity AF-2 domain binding nuclear receptor coactivator activity RNA binding nucleic acid binding transcription factor binding estrogen receptor binding Cellular component mediator complex mitochondrion nucleus nucleoplasm Biological process mitochondrial transcription regulation of transcription, DNA-templated ossification actin filament organization positive regulation of osteoclast differentiation positive regulation of DNA-binding transcription factor activity response to glucocorticoid bone trabecula formation positive regulation of bone resorption transcription, DNA-templated positive regulation of transcription, DNA-templated cellular response to reactive oxygen species positive regulation of alkaline phosphatase activity response to cAMP positive regulation of phosphorylation negative regulation of transcription, DNA-templated intracellular estrogen receptor signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of cold-induced thermogenesis regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 133522 170826 Ensembl ENSG00000155846 ENSMUSG00000033871 UniProt Q86YN6 Q8VHJ7 RefSeq (mRNA) NM_001172698 NM_001172699 NM_133263 NM_133249 NM_001364996 RefSeq (protein) NP_001166169 NP_001166170 NP_573570 NP_573512 NP_001351925 Location (UCSC) Chr 5: 149.73 – 149.86 Mb Chr 18: 61.43 – 61.53 Mb PubMed search [3] [4]
Wikidata
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See also

• PPARGC1A
• Peroxisome proliferator-activated receptor
• Peroxisome proliferator-activated receptor alpha
• Peroxisome proliferator-activated receptor delta
• Peroxisome proliferator-activated receptor gamma
• Transcription coregulator