PPFIBP1

Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene.^[5][6][7]

PPFIBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TAD
Identifiers
Aliases	PPFIBP1, L2, SGT2, hSGT2, hSgt2p, PPFIA binding protein 1
External IDs	OMIM: 603141; MGI: 1914783; HomoloGene: 2685; GeneCards: PPFIBP1; OMA:PPFIBP1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.23-p11.22 Start 27,523,431 bp[1] End 27,695,564 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G3 Start 146,789,985 bp[2] End 146,933,523 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii sural nerve buccal mucosa cell epithelium of colon left ovary Achilles tendon trigeminal ganglion ventricle of the heart left ventricle right ventricle Top expressed in tail of embryo cumulus cell hand otolith organ utricle endothelial cell of lymphatic vessel cervix conjunctival fornix seminal vesicula semi-lunar valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cadherin binding Cellular component plasma membrane focal adhesion cytosol Biological process cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8496 67533 Ensembl ENSG00000110841 ENSMUSG00000016487 UniProt Q86W92 Q8C8U0 RefSeq (mRNA) NM_001198915 NM_001198916 NM_003622 NM_177444 NM_001170433 NM_026221 NM_001355728 NM_001355729 RefSeq (protein) NP_001185844 NP_001185845 NP_003613 NP_803193 NP_001163904 NP_080497 NP_001342657 NP_001342658 Location (UCSC) Chr 12: 27.52 – 27.7 Mb Chr 6: 146.79 – 146.93 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]

Interactions

PPFIBP1 has been shown to interact with liprin-alpha-1.^[5]