PPM1B

Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.^[5][6]

PPM1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P8E
Identifiers
Aliases	PPM1B, PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX, protein phosphatase, Mg2+/Mn2+ dependent 1B
External IDs	OMIM: 603770; MGI: 101841; HomoloGene: 2027; GeneCards: PPM1B; OMA:PPM1B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 44,167,969 bp[1] End 44,244,384 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E4|17 55.13 cM Start 85,264,169 bp[2] End 85,331,419 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Epithelium of choroid plexus retinal pigment epithelium gastrocnemius muscle biceps brachii Skeletal muscle tissue of rectus abdominis muscle of thigh Skeletal muscle tissue of biceps brachii deltoid muscle glutes Top expressed in neural layer of retina ankle spermatid muscle of thigh digastric muscle temporal muscle saccule sternocleidomastoid muscle body of femur cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding magnesium ion binding manganese ion binding protein serine/threonine phosphatase activity phosphoprotein phosphatase activity catalytic activity cation binding hydrolase activity metal ion binding Cellular component membrane cytoplasm nucleolus cytosol nucleus Biological process protein dephosphorylation negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of defense response to virus N-terminal protein myristoylation peptidyl-threonine dephosphorylation negative regulation of interferon-beta production negative regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5495 19043 Ensembl ENSG00000138032 ENSMUSG00000061130 UniProt O75688 P36993 RefSeq (mRNA) NM_001033556 NM_001033557 NM_002706 NM_177968 NM_177969 NM_001159496 NM_001159497 NM_001159498 NM_011151 RefSeq (protein) NP_001028729 NP_002697 NP_808907 NP_808908 NP_001152968 NP_001152969 NP_001152970 NP_035281 Location (UCSC) Chr 2: 44.17 – 44.24 Mb Chr 17: 85.26 – 85.33 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.^[6]

Interactions

PPM1B has been shown to interact with:

• CDK2,^[7]
• CDK6,^[7]
• CHUK,^[8]
• IKBKG,^[8]
• IKK2,^[8]
• MAP3K7,^[9] and
• PPARγ.^[10]