PPP1R10

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.^[5][6][7]

PPP1R10
Identifiers
Aliases	PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99, protein phosphatase 1 regulatory subunit 10
External IDs	OMIM: 603771; MGI: 1289273; HomoloGene: 2033; GeneCards: PPP1R10; OMA:PPP1R10 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,600,413 bp[1] End 30,618,612 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.77 cM Start 36,227,326 bp[2] End 36,243,175 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell sural nerve gallbladder tonsil granulocyte appendix urinary bladder right uterine tube rectum Achilles tendon Top expressed in primary oocyte zygote tail of embryo testicle secondary oocyte genital tubercle spermatid spermatocyte ventricular zone uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase inhibitor activity DNA binding metal ion binding RNA binding protein binding Cellular component chromatin PTW/PP1 phosphatase complex nucleus nucleoplasm nuclear body Biological process negative regulation of catalytic activity protein import into nucleus negative regulation of cardiac muscle cell apoptotic process positive regulation of telomere maintenance negative regulation of phosphoprotein phosphatase activity negative regulation of mitotic DNA damage checkpoint Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5514 52040 Ensembl ENSG00000227804 ENSG00000238104 ENSG00000206489 ENSG00000230995 ENSG00000235291 ENSG00000231737 ENSG00000204569 ENSMUSG00000039220 UniProt Q96QC0 Q80W00 RefSeq (mRNA) NM_002714 NM_001376195 NM_001163818 NM_175934 NM_001357740 RefSeq (protein) NP_002705 NP_001363124 NP_001157290 NP_001344669 NP_001390493 Location (UCSC) Chr 6: 30.6 – 30.62 Mb Chr 17: 36.23 – 36.24 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.^[7]